Medicinal Chemistry of Nicotinamide in the Treatment of Ischemia and Reperfusion

Authors: Yang J.; Klaidman L.K.; Adams J.D.

Source: Mini Reviews in Medicinal Chemistry, Volume 2, Number 2, April 2002 , pp. 125-134(10)

Publisher: Bentham Science Publishers

Key:

- Free Content

- New Content

- Subscribed Content

- Free Trial Content

Abstract:

Nicotinamide can facilitate DNA repair by inhibiting poly(ADP-ribose) polymerase, increasing NAD levels and adjusting other related enzyme activities. This review will summarize recent work on the design of poly(ADP-ribose) polymerase inhibitors, poly(ADP-ribose) glycohydrolase inhibitors and will discuss the possible use of drugs that interact with NAD synthetic enzymes.

Keywords: nicotinamide; poly(adp-ribose) polymerase inhibitors; poly(adp-ribose)glycohydrolase inhibitors; nicotinamide; glycohydrolase

Language: English

Document Type: Review article

DOI: 10.2174/1389557024605483

The full text electronic article is available for purchase. You will be able to download the full text electronic article after payment.

$55.10 plus tax Refund Policy