Medicinal Chemistry of Nicotinamide in the Treatment of Ischemia and Reperfusion

Authors: Yang J.; Klaidman L.K.; Adams J.D.

Source: Mini Reviews in Medicinal Chemistry, Volume 2, Number 2, April 2002 , pp. 125-134(10)

Publisher: Bentham Science Publishers

Buy & download fulltext article:

Price: $63.10 plus tax (Refund Policy)

Abstract:

Nicotinamide can facilitate DNA repair by inhibiting poly(ADP-ribose) polymerase, increasing NAD levels and adjusting other related enzyme activities. This review will summarize recent work on the design of poly(ADP-ribose) polymerase inhibitors, poly(ADP-ribose) glycohydrolase inhibitors and will discuss the possible use of drugs that interact with NAD synthetic enzymes.

Keywords: nicotinamide; poly(adp-ribose) polymerase inhibitors; poly(adp-ribose)glycohydrolase inhibitors; nicotinamide; glycohydrolase

Language: English

Document Type: Review article

DOI: http://dx.doi.org/10.2174/1389557024605483

Publication date: 2002-04-01

More about this publication?

The aim of Mini-Reviews in Medicinal Chemistry is to publish short reviews on the important recent developments in medicinal chemistry and allied disciplines.

The scope of Mini-Reviews in Medicinal Chemistry will cover all areas of medicinal chemistry including developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, drug targets, and natural product research and structure-activity relationship studies.

Mini-Reviews in Medicinal Chemistry is an essential journal for every medicinal and pharmaceutical chemist who wishes to be kept informed and up-to-date with the latest and most important developments.