Molecular Pharmacophore Determination of Lipid Lowering Drugs with the Receptor Mapping Method

Authors: Ablise M.; Cartier A.; Siest G.; Visvikis S.; Loppinet V.

Source: Mini Reviews in Medicinal Chemistry, Volume 2, Number 2, April 2002 , pp. 97-102(6)

Publisher: Bentham Science Publishers

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Abstract:

Hypolipidemic pharmacophoric moieties of statins, fibrates, ACAT inhibitors and beta-sitosterol analog series were identified by computational modeling, and compared with the computed structure of new potential glycyrrhetinic acid derivatives lipid-lowering drugs. Their electronic and geometric domains, similar to those of fibrates, suggest a fibrate -like mechanism matching biochemical data.

Keywords: acat inhibitors; molecular modeling; glycyrrhizin; glycyrrhiza glabra

Language: English

Document Type: Review article

DOI: 10.2174/1389557024605528

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