Transgenic Mouse Models with Tau Pathology to Test Therapeutic Agents for Alzheimer's Disease

Authors: Hernandez F.; Lim F.; Lucas J.J.; Perez-Martin C.; Moreno F.; Avila J.

Source: Mini Reviews in Medicinal Chemistry, Volume 2, Number 1, February 2002 , pp. 51-58(8)

Publisher: Bentham Science Publishers

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Abstract:

The deposit of two proteins in the brain characterizes Alzheimer's disease: deposits of bgr -amyloid protein to form senile plaques and tau protein in neurofibrillary tangles. This review discusses transgenic animals overexpressing normal or mutated tau protein as well as kinases involved in tau hyperphosphorylation. These animals hold a great potential as tools to test the effects of forthcoming therapeutical agents for Alzheimer's disease.

Keywords: Tau Pathology; Alzheimers Disease; tau hyperphosphorylation

Language: English

Document Type: Review article

DOI: http://dx.doi.org/10.2174/1389557023406557

Publication date: 2002-02-01

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The aim of Mini-Reviews in Medicinal Chemistry is to publish short reviews on the important recent developments in medicinal chemistry and allied disciplines.

The scope of Mini-Reviews in Medicinal Chemistry will cover all areas of medicinal chemistry including developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, drug targets, and natural product research and structure-activity relationship studies.

Mini-Reviews in Medicinal Chemistry is an essential journal for every medicinal and pharmaceutical chemist who wishes to be kept informed and up-to-date with the latest and most important developments.