Non-Cholinergic Pharmacotherapy Approaches to the Future Treatment of Alzheimer's Disease

Authors: Castro A.; Conde S.; Rodriguez-Franco M.Isabel; Martinez A.

Source: Mini Reviews in Medicinal Chemistry, Volume 2, Number 1, February 2002 , pp. 37-50(8)

Publisher: Bentham Science Publishers

Abstract:

Research on the molecular basis of Alzheimer's disease has elucidated pathogenic pathways from which a range of rational pharmacological interventions has emerged. The most promising strategies involve approaches to retarding, halting or preventing the formation or accumulation of beta amyloid plaques and neurofibrillary tangles. Other therapeutic approaches include those acting via excitatory amino acid receptors, limiting the oxidative stress and inflammatory response associated with dementia, molecules with nerve growth factor like activity. In the present article these and the other recent advances in the neurobiology and pharmacotherapy of AD will be reviewed.

Keywords: Non-Cholinergic Pharmacotherapy; Alzheimers Disease; neurofibrillary tangles; ampakines; acetylcholinesterase (AChE); Tau Hyperphosphorylation; calmoduline kinase

Language: English

Document Type: Review article

DOI: http://dx.doi.org/10.2174/1389557023406610

Publication date: 2002-02-01

• The aim of Mini-Reviews in Medicinal Chemistry is to publish short reviews on the important recent developments in medicinal chemistry and allied disciplines.
  
  The scope of Mini-Reviews in Medicinal Chemistry will cover all areas of medicinal chemistry including developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, drug targets, and natural product research and structure-activity relationship studies.
  
  Mini-Reviews in Medicinal Chemistry is an essential journal for every medicinal and pharmaceutical chemist who wishes to be kept informed and up-to-date with the latest and most important developments.

• In this: publication
• By this: publisher
• In this Subject: Chemistry (General) ,  Pharmacology
• By this author: Castro A. ;  Conde S. ;  Rodriguez-Franco M.Isabel ;  Martinez A.

Website © Publishing Technology. Article copyright remains with the publisher, society or author(s) as specified within the article.

• Terms and conditions
• Privacy policy
• Information for advertisers