Non-Cholinergic Pharmacotherapy Approaches to the Future Treatment of Alzheimer's Disease

Authors: Castro A.; Conde S.; Rodriguez-Franco M.Isabel; Martinez A.

Source: Mini Reviews in Medicinal Chemistry, Volume 2, Number 1, February 2002 , pp. 37-50(8)

Publisher: Bentham Science Publishers

Key:

- Free Content

- New Content

- Subscribed Content

- Free Trial Content

Abstract:

Research on the molecular basis of Alzheimer's disease has elucidated pathogenic pathways from which a range of rational pharmacological interventions has emerged. The most promising strategies involve approaches to retarding, halting or preventing the formation or accumulation of beta amyloid plaques and neurofibrillary tangles. Other therapeutic approaches include those acting via excitatory amino acid receptors, limiting the oxidative stress and inflammatory response associated with dementia, molecules with nerve growth factor like activity. In the present article these and the other recent advances in the neurobiology and pharmacotherapy of AD will be reviewed.

Keywords: Non-Cholinergic Pharmacotherapy; Alzheimers Disease; neurofibrillary tangles; ampakines; acetylcholinesterase (AChE); Tau Hyperphosphorylation; calmoduline kinase

Language: English

Document Type: Review article

DOI: 10.2174/1389557023406610

The full text electronic article is available for purchase. You will be able to download the full text electronic article after payment.

$55.10 plus tax Refund Policy