Technological Advances in Antigen Delivery and Synthetic Peptide Vaccine Developmental Strategies

Authors: Olive C.; Toth I.; Jackson D.

Source: Mini Reviews in Medicinal Chemistry, Volume 1, Number 4, November 2001 , pp. 429-438(11)

Publisher: Bentham Science Publishers

Key:

- Free Content

- New Content

- Subscribed Content

- Free Trial Content

Abstract:

Significant advances have been made in the field of peptide chemistry, especially in the design of synthetic peptide immunogens which has led to new concepts and strategies for human vaccine development. This article reviews some of these technological advances and approaches to vaccine design including the multiple antigenic peptide system, the lipid polylysine core peptide system, the polymerization of peptides into multivalent immunogens and self adjuvanting synthetic peptide-based immunogens.

Keywords: receptor (TCR); antigen presenting cells (APC); immunogens; B-cell epitopes

Language: English

Document Type: Review article

DOI: 10.2174/1389557013406666

The full text electronic article is available for purchase. You will be able to download the full text electronic article after payment.

$55.10 plus tax Refund Policy