Technological Advances in Antigen Delivery and Synthetic Peptide Vaccine Developmental Strategies

Authors: Olive C.; Toth I.; Jackson D.

Source: Mini Reviews in Medicinal Chemistry, Volume 1, Number 4, November 2001 , pp. 429-438(11)

Publisher: Bentham Science Publishers

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Abstract:

Significant advances have been made in the field of peptide chemistry, especially in the design of synthetic peptide immunogens which has led to new concepts and strategies for human vaccine development. This article reviews some of these technological advances and approaches to vaccine design including the multiple antigenic peptide system, the lipid polylysine core peptide system, the polymerization of peptides into multivalent immunogens and self adjuvanting synthetic peptide-based immunogens.

Keywords: receptor (TCR); antigen presenting cells (APC); immunogens; B-cell epitopes

Language: English

Document Type: Review article

DOI: http://dx.doi.org/10.2174/1389557013406666

Publication date: 2001-11-01

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The aim of Mini-Reviews in Medicinal Chemistry is to publish short reviews on the important recent developments in medicinal chemistry and allied disciplines.

The scope of Mini-Reviews in Medicinal Chemistry will cover all areas of medicinal chemistry including developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, drug targets, and natural product research and structure-activity relationship studies.

Mini-Reviews in Medicinal Chemistry is an essential journal for every medicinal and pharmaceutical chemist who wishes to be kept informed and up-to-date with the latest and most important developments.