Antibody Directed Enzyme Prodrug Therapy (ADEPT) and Related Approaches for Anticancer Therapy

Author: Jung M.

Source: Mini Reviews in Medicinal Chemistry, Volume 1, Number 4, November 2001 , pp. 399-407(12)

Publisher: Bentham Science Publishers

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Abstract:

In antibody directed enzyme prodrug therapy (ADEPT) an antibody bound enzyme is targeted to tumor cells. This allows for selective activation of a nontoxic prodrug to a cytotoxic agent at the tumor site for cancer therapy. Site-selective prodrug activation results in reduced side effects in remote tissue. This article reviews ADEPT with emphasis on the chemical viewpoint and recent developments.

Keywords: Antibody Directed Enzyme Prodrug Therapy; ADEPT; Anticancer Therapy; Alkaline Phosphatase; Amino Peptidases; Aryl Sulfatase; Carboxylesterase; Carboxypeptidase A; Carboxypeptidase G2 (CpG2); Cytosine Deaminase

Language: English

Document Type: Review article

DOI: 10.2174/1389557013406747

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