Non Peptidic Ligands at the Opioid Receptor Like-1 (ORL-1)

Authors: Barlocco D.; Toma L.; Cignarella G.

Source: Mini Reviews in Medicinal Chemistry, Volume 1, Number 4, November 2001 , pp. 363-375(13)

Publisher: Bentham Science Publishers

Buy & download fulltext article:

Price: $63.10 plus tax (Refund Policy)

Abstract:

Opioid receptor like-1 (ORL-1) has recently been indicated as a potentially useful target for the treatment of a number of central disorders and several other diseases.

This review deals with non-peptidic ligands at the ORL-1 receptor, focusing on their structural and binding properties. Agonism or antagonism evidenced from functional experiments is also commented. For some compounds, possible therapeutic applications are considered.

Keywords: Opioid Receptor Like-1 (ORL-1); Nociceptin (orphanin FQ); Dynorphin A

Language: English

Document Type: Review article

DOI: http://dx.doi.org/10.2174/1389557013406657

Publication date: 2001-11-01

More about this publication?

The aim of Mini-Reviews in Medicinal Chemistry is to publish short reviews on the important recent developments in medicinal chemistry and allied disciplines.

The scope of Mini-Reviews in Medicinal Chemistry will cover all areas of medicinal chemistry including developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, drug targets, and natural product research and structure-activity relationship studies.

Mini-Reviews in Medicinal Chemistry is an essential journal for every medicinal and pharmaceutical chemist who wishes to be kept informed and up-to-date with the latest and most important developments.