Non Peptidic Ligands at the Opioid Receptor Like-1 (ORL-1)

Authors: Barlocco D.; Toma L.; Cignarella G.

Source: Mini Reviews in Medicinal Chemistry, Volume 1, Number 4, November 2001 , pp. 363-375(13)

Publisher: Bentham Science Publishers

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Abstract:

Opioid receptor like-1 (ORL-1) has recently been indicated as a potentially useful target for the treatment of a number of central disorders and several other diseases.

This review deals with non-peptidic ligands at the ORL-1 receptor, focusing on their structural and binding properties. Agonism or antagonism evidenced from functional experiments is also commented. For some compounds, possible therapeutic applications are considered.

Keywords: Opioid Receptor Like-1 (ORL-1); Nociceptin (orphanin FQ); Dynorphin A

Language: English

Document Type: Review article

DOI: 10.2174/1389557013406657

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