Fullerenes in Medicinal Chemistry and their Biological Applications

Authors: Tagmatarchis N.; Shinohara H.

Source: Mini Reviews in Medicinal Chemistry, Volume 1, Number 4, November 2001 , pp. 339-348(10)

Publisher: Bentham Science Publishers

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Abstract:

The isolation and preparation ten years ago of the fullerenes in bulk quantities, sparked off a truly remarkable interdisciplinary research activity, encompassing diverse fields of chemistry, physics, materials science and medicinal chemistry. Pharmaceutical and biological studies have revealed that fullerene-based compounds exhibit various types of biological activity either in vitro or in vivo and are discussed in this review.

Keywords: Fullerenes; UV-Visible absorption; Photodynamic Therapy; Enzymatic Inhibition; Cell signaling; Apoptosis; Neuroprotective antioxidants; Endohedral Metallofullerenes; MRI contrast agents

Language: English

Document Type: Review article

DOI: http://dx.doi.org/10.2174/1389557013406693

Publication date: 2001-11-01

More about this publication?

The aim of Mini-Reviews in Medicinal Chemistry is to publish short reviews on the important recent developments in medicinal chemistry and allied disciplines.

The scope of Mini-Reviews in Medicinal Chemistry will cover all areas of medicinal chemistry including developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, drug targets, and natural product research and structure-activity relationship studies.

Mini-Reviews in Medicinal Chemistry is an essential journal for every medicinal and pharmaceutical chemist who wishes to be kept informed and up-to-date with the latest and most important developments.