Fullerenes in Medicinal Chemistry and their Biological Applications

Authors: Tagmatarchis N.; Shinohara H.

Source: Mini Reviews in Medicinal Chemistry, Volume 1, Number 4, November 2001 , pp. 339-348(10)

Publisher: Bentham Science Publishers

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Abstract:

The isolation and preparation ten years ago of the fullerenes in bulk quantities, sparked off a truly remarkable interdisciplinary research activity, encompassing diverse fields of chemistry, physics, materials science and medicinal chemistry. Pharmaceutical and biological studies have revealed that fullerene-based compounds exhibit various types of biological activity either in vitro or in vivo and are discussed in this review.

Keywords: Fullerenes; UV-Visible absorption; Photodynamic Therapy; Enzymatic Inhibition; Cell signaling; Apoptosis; Neuroprotective antioxidants; Endohedral Metallofullerenes; MRI contrast agents

Language: English

Document Type: Review article

DOI: 10.2174/1389557013406693

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