Recent Advances in the Medicinal Chemistry of Polyamine Toxins

Authors: Stromgaard K.; Andersen K.; Krogsgaard-Larsen P.; Jaroszewski J.W.

Source: Mini Reviews in Medicinal Chemistry, Volume 1, Number 4, November 2001 , pp. 317-338(22)

Publisher: Bentham Science Publishers

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Abstract:

This review describes the recent developments in the field of polyamine toxins, with focus on structure activity relationship investigations, including studies of importance of the polyamine moiety for biological activity, photolabeling studies using polyamine toxins as templates, as well as use of solid phase methods for the synthesis of polyamine toxins. The review is mainly concerned with effects of polyamine toxins on nicotinic acetylcholine receptors and ionotropic glutamate receptors.

Keywords: Polyamine Toxins; Synthesis; Argiope lobata; Nephilia clavata; Nephilia maculata; Dolomedes okefinokensis; Hebestatis theveniti; Hololenta curta; Araneidae; Philanthus triangulum

Language: English

Document Type: Review article

DOI: http://dx.doi.org/10.2174/1389557013406738

Publication date: 2001-11-01

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The aim of Mini-Reviews in Medicinal Chemistry is to publish short reviews on the important recent developments in medicinal chemistry and allied disciplines.

The scope of Mini-Reviews in Medicinal Chemistry will cover all areas of medicinal chemistry including developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, drug targets, and natural product research and structure-activity relationship studies.

Mini-Reviews in Medicinal Chemistry is an essential journal for every medicinal and pharmaceutical chemist who wishes to be kept informed and up-to-date with the latest and most important developments.