Peripheral and Dual Binding Site Acetylcholinesterase Inhibitors: Implications in treatment of Alzheimer's Disease

Authors: Castro A.; Martinez A.

Source: Mini Reviews in Medicinal Chemistry, Volume 1, Number 3, September 2001 , pp. 267-272(8)

Publisher: Bentham Science Publishers

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Abstract:

Recently advances in understanding the molecular basis of Alzheimers disease have led to the consideration of the relationship between cholinergic inhibitors and amyloid deposition as a new hypothesis for the future rational design of effective anti-Alzheimer drugs. In the present review, the non-cholinergic functions of acetylcholinesterase (AChE) and the therapeutic potential of peripheral and dual binding site AChE inhibitors in delaying the neurodegenerative process will be discussed.

Keywords: Acetylcholinesterase Inhibitors; Alzheimers Disease; Anti-Alzheimer drugs

Language: English

Document Type: Review article

DOI: 10.2174/1389557013406864

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