Antihypertensive Drugs that Act on Renin-Angiotensin System with Emphasis in AT1 Antagonists
Authors: Mavromoustakos T.; Apostolopoulos V.; Matsoukas J.
Source: Mini Reviews in Medicinal Chemistry, Volume 1, Number 2, July 2001 , pp. 207-217(11)
Publisher: Bentham Science Publishers
Abstract:
Angiotensin II, the primary active hormone in the Renin-Angiotensin System is a major vasoconstrictor implicated in the cause of hypertension. Research efforts have focused in the treatment of disease by blocking its release and more recently by competing its action on AT 1 receptors. This approach generated in the pharmaceutical market, losartan, and other derivatives. To better understand the stereoelectronic requirements that lead to the molecular basis of hypertension the stereochemical features of angiotensin II and its antagonists are studied.
Keywords: Antihypertensive Drugs; Renin-Angiotensin System; AT1 Antagonists; Angiotensin; RENIN ANGIOTENSIN SYSTEM; ANGIOTENSIN-CONVERTING ENZYME (ACE) INHIBITORS; RENIN INHIBITORS; Captopril; Enlapril; Remikiren
Language: English
Document Type: Review article
DOI: http://dx.doi.org/10.2174/1389557013407115
Publication date: 2001-07-01
- The aim of Mini-Reviews in Medicinal Chemistry is to publish short reviews on the important recent developments in medicinal chemistry and allied disciplines.
The scope of Mini-Reviews in Medicinal Chemistry will cover all areas of medicinal chemistry including developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, drug targets, and natural product research and structure-activity relationship studies.
Mini-Reviews in Medicinal Chemistry is an essential journal for every medicinal and pharmaceutical chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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- By this: publisher
- In this Subject: Chemistry (General) , Pharmacology
- By this author: Mavromoustakos T. ; Apostolopoulos V. ; Matsoukas J.

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