Quantitative Structure-Activity Relationship (QSAR) Paradigm - Hansch Era to New Millennium

Author: Debnath A.Kumar

Source: Mini Reviews in Medicinal Chemistry, Volume 1, Number 2, July 2001 , pp. 187-195(9)

Publisher: Bentham Science Publishers

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Abstract:

The analysis of structure-activity relationships started probably more than hundred years ago but the concept of quantitatively correlating physicochemical properties of molecules with their biological activities, termed as quantitative structure-activity relationship (QSAR), was initiated by Corwin Hansch and his groups in early 1960. Many new methods have emerged since then. The concept evolved from 2D QSAR to 3D QSAR and lately another dimension (4D QSAR) has been added. This evolution is briefly reviewed here.

Keywords: quantitative structure-activity relationship (QSAR; Hologram QSAR; Inverse QSAR; Binary QSAR; QSAR METHODS

Language: English

Document Type: Review article

DOI: http://dx.doi.org/10.2174/1389557013407061

Publication date: 2001-07-01

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The aim of Mini-Reviews in Medicinal Chemistry is to publish short reviews on the important recent developments in medicinal chemistry and allied disciplines.

The scope of Mini-Reviews in Medicinal Chemistry will cover all areas of medicinal chemistry including developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, drug targets, and natural product research and structure-activity relationship studies.

Mini-Reviews in Medicinal Chemistry is an essential journal for every medicinal and pharmaceutical chemist who wishes to be kept informed and up-to-date with the latest and most important developments.