Therapeutic Applications of Sugar-Mimicking Glycosidase Inhibitors

Authors: Asano N.; Kato A.; Watson A.A.

Source: Mini Reviews in Medicinal Chemistry, Volume 1, Number 2, July 2001 , pp. 145-154(10)

Publisher: Bentham Science Publishers

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Abstract:

Sugar-mimicking alkaloids inhibit the glycosidases involved in a wide range of important biological processes, principally owing to their structural resemblance to the sugar moiety of the natural substrate. The possibility of modifying and blocking these processes by using such inhibitors for therapeutic applications has attracted a lot of attention.

Keywords: Glycosidase Inhibitors; glycosidases; Castanospermine; Castanospermum australe; glucosidase inhibitors; Casuarina equisetifolia; Actinoplanes; antidiabetic agents; MANNOSIDASE INHIBITORS

Language: English

Document Type: Review article

DOI: 10.2174/1389557013407052

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