Small Molecule Inhibitors of Serine Threonine Protein Phosphatases

Authors: McCluskey A.; Sakoff J.A.

Source: Mini Reviews in Medicinal Chemistry, Volume 1, Number 1, May 2001 , pp. 43-55(13)

Publisher: Bentham Science Publishers

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Abstract:

Serine(slash)threonine protein phosphatases have long been ignored as potential therapeutic targets for two reasons, one the biochemical significance of these proteins has not been appreciated and two, many natural protein phosphatase inhibitors are potent toxins and are considered unsuitable for clinical use. This review outlines the biochemical role of this protein family in cancer, cystic fibrosis, immunosuppression and, cardiac and neurological disorders. Particular emphasis is also given to the synthesis of selective small molecule inhibitors and their clinical

Keywords: Molecule Inhibitors; Protein Phosphatases; phosphorylation; C terminal; PP1 and PP2A; Gene mutations; myopathic disease; okadaic acid; cantharidin analogues; family of Coleoptera; alfalfahay

Language: English

Document Type: Review article

DOI: http://dx.doi.org/10.2174/1389557013407205

Publication date: 2001-05-01

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The aim of Mini-Reviews in Medicinal Chemistry is to publish short reviews on the important recent developments in medicinal chemistry and allied disciplines.

The scope of Mini-Reviews in Medicinal Chemistry will cover all areas of medicinal chemistry including developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, drug targets, and natural product research and structure-activity relationship studies.

Mini-Reviews in Medicinal Chemistry is an essential journal for every medicinal and pharmaceutical chemist who wishes to be kept informed and up-to-date with the latest and most important developments.