Recent Advances in Bioreductive Drug Targeting

Authors: Naylor M.A.; Thomson P.

Source: Mini Reviews in Medicinal Chemistry, Volume 1, Number 1, May 2001 , pp. 17-29(13)

Publisher: Bentham Science Publishers

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Abstract:

Advances in the chemistry of bioreductive drug activation have led to the design of hypoxia-selective drug delivery systems. These prodrugs, comprising a bioreductive trigger, linker and effector were first explored with nitrobenzyl quaternary ammonium mustards. Alternative nitroheterocycles were subsequently developed, together with new avenues of prodrug activation in ADEPT and GDEPT. Major advances have also been made in utilising indolequinone reductive chemistry based upon an appreciation of the kinetics of oxygen-sensitive reductive elimination.

Keywords: Bioreductive Drug Targeting; ammonium mustards; cytotoxic chemotherapeutic drugs; radiosensitisers; superoxide radicals; nitrogen atom; diethyl dithiocarbamate; carbamate linker; Bergman cyclisation; nitroimidazole trigger; cyclopropamitosenes

Language: English

Document Type: Review article

DOI: http://dx.doi.org/10.2174/1389557013407241

Publication date: 2001-05-01

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The aim of Mini-Reviews in Medicinal Chemistry is to publish short reviews on the important recent developments in medicinal chemistry and allied disciplines.

The scope of Mini-Reviews in Medicinal Chemistry will cover all areas of medicinal chemistry including developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, drug targets, and natural product research and structure-activity relationship studies.

Mini-Reviews in Medicinal Chemistry is an essential journal for every medicinal and pharmaceutical chemist who wishes to be kept informed and up-to-date with the latest and most important developments.