Modifying TNF alpha for Therapeutic Use A Perspective on the TNF Receptor System

Authors: Hasegawa A.; Takasaki W.; Greene M.I.; Murali R.

Source: Mini Reviews in Medicinal Chemistry, Volume 1, Number 1, May 2001 , pp. 5-16(12)

Publisher: Bentham Science Publishers

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Abstract:

TNF alpha is an inflammatory mediator that is relevant to several autoimmune diseases. Macromolecular inhibitors of TNF alpha have proven therapeutically useful in some preliminary studies. We have developed small molecule TNF alpha antagonist based on the crystal structure of TNF receptor complex. The TNF alpha inhibitor is specific and mediates biological function similar to the inhibitory soluble TNF receptor. This review focuses on development of small molecule anti-TNF alpha mimetics by us and current status of other agents.

Keywords: Modifying TNF; inflammatory mediator; TNF receptor; transplantable tumors; destructive arthritis; CDR loops; Neutralizing antibodies; constraining cysteine residues; peptidomimetics; Cyclic peptides; EAE conditions

Language: English

Document Type: Review article

DOI: http://dx.doi.org/10.2174/1389557013407214

Publication date: 2001-05-01

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The aim of Mini-Reviews in Medicinal Chemistry is to publish short reviews on the important recent developments in medicinal chemistry and allied disciplines.

The scope of Mini-Reviews in Medicinal Chemistry will cover all areas of medicinal chemistry including developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, drug targets, and natural product research and structure-activity relationship studies.

Mini-Reviews in Medicinal Chemistry is an essential journal for every medicinal and pharmaceutical chemist who wishes to be kept informed and up-to-date with the latest and most important developments.