Synthesis of (±) Travoprost and its Analogs
A new synthetic approach for the antiglaucoma agent, travoprost (1) has been developed in four steps from key intermediate (2). Key transformations include Horner-Wadsworth-Emmons reaction and separation of diastereomers to obtain (±) travoprost (1) and its analogs.
Keywords: (±) travoprost; Phosphonate; Prostaglandins; alkylation; antiglaucoma; dimethoxyethane; dimethyl; methane; n-BuLi; phosphonate
Document Type: Research Article
Publication date: 01 May 2011
- Letters in Organic Chemistry publishes original letters on all areas of organic chemistry including synthesis, bioorganic, medicinal, natural products, organometallic, supramolecular, molecular recognition and physical organic chemistry. The emphasis is placed on publishing quality papers very rapidly. Letters are processed rapidly and take full advantage of the Internet technology both for the submission and the review of the manuscripts.
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