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A Practical Approach Towards Synthesis of Octahydroquinazolinone Derivatives in Water

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A simple, efficient and green procedure has been developed for the synthesis of octahydroquinazolinone derivatives by Biginelli-type three-component cyclocondensation reactions of cyclic β-diketones, aldehydes and (thio)urea with p-TsOH catalysis in water.

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Keywords: Octahydroquinazolinone; biginelli reaction; catalysis; cyclic β-diketones; p-toluenesulfonic acid; synthesis

Document Type: Research Article

Publication date: 2009-10-01

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  • Letters in Organic Chemistry publishes original letters on all areas of organic chemistry including synthesis, bioorganic, medicinal, natural products, organometallic, supramolecular, molecular recognition and physical organic chemistry. The emphasis is placed on publishing quality papers very rapidly. Letters are processed rapidly and take full advantage of the Internet technology both for the submission and the review of the manuscripts.
    The journal is essential reading for all organic chemists both in academia and industry.
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