A Model for Predicting the Optimal Conditions for Labeling the Carbohydrates with the Amine Derivatives by Reductive Amination (Supplementry Material)

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Abstract:

The reaction of the primary amine species with the carbohydrate's reducing end moieties is a kind of special reductive amination reactions which need acid catalysis. The rate equation and selectivity equation of this kind of reactions were given by the kinetic and thermodynamic theories, which can predict the influence of the reaction temperature, pKa of used amine and pH on the reaction rate and yield. Based on this theoretical model, researchers can design their route and set the appropriate reaction conditions for immobilization of the carbohydrates or preparation of the carbohydrate conjugates.





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  • Letters in Organic Chemistry publishes original letters on all areas of organic chemistry including synthesis, bioorganic, medicinal, natural products, organometallic, supramolecular, molecular recognition and physical organic chemistry. The emphasis is placed on publishing quality papers very rapidly. Letters are processed rapidly and take full advantage of the Internet technology both for the submission and the review of the manuscripts.
    The journal is essential reading for all organic chemists both in academia and industry.
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