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A Convenient One Pot Synthesis of 3-Cyano-9-methyl-2-methylthio-4-oxo- 4H- pyrimido[2,1-b] pyrimido [4,5-b] Quinoline and its Reactions with Selected Nucleophiles

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3-Amino-8-methyl pyrimido [4,5-b] quinoline (1) in N,N-dimethyl formamide (DMF) and anhydrous potassium carbonate reacted with ethyl-2-cyano-3,3-bismethyl thioacrylate 2 to afford novel heterocyclic compound 3- cyano-9-methyl-2-methylthio-4-oxo-4H-pyrimido [4,5-b] quinoline 3. The latter were further reacted with selected N-, Oand C- nucleophiles such as arylamines, substituted phenols, heterylamines and compounds with an active methylene group.

Keywords: N,N-dimethyl formamide; One pot synthesis; ketene dithioacetals; pyrimidine ring; pyrimido quinoline; ring anellation

Document Type: Research Article


Publication date: 2009-10-01

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  • Letters in Organic Chemistry publishes original letters on all areas of organic chemistry including synthesis, bioorganic, medicinal, natural products, organometallic, supramolecular, molecular recognition and physical organic chemistry. The emphasis is placed on publishing quality papers very rapidly. Letters are processed rapidly and take full advantage of the Internet technology both for the submission and the review of the manuscripts.
    The journal is essential reading for all organic chemists both in academia and industry.
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