Isolation, Characterization and Hypoglycemic Activity of an Acid Polysaccharide Isolated from Schisandra chinensis (Turcz.) Baill

Authors: Gao, Xiaoxv; Meng, Xianjun; Li, Jihai; Tong, Haibin

Source: Letters in Organic Chemistry, Volume 6, Number 5, July 2009 , pp. 428-433(6)

Publisher: Bentham Science Publishers

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Abstract:

The crude polysaccharide (SCP) extracted from Schisandra chinensis by hot water extraction and ethanol precipitation, was further fractionated by DEAE-cellulose and Sephacryl S-300 chromatography, giving a polysaccharide fraction named as SCP-BII. The molecular weight of SCP-BII was 23 kDa using HPGPC. Gas chromatography analysis suggested that SCP-BII was composed of rhamnose, arabinose, mannose, galactose, glucose and galacturonic acid with a ratio of 4.7:2.6:0.8:5.6:1:5.6. Pharmaceutical experiments showed SCP-BII administered in alloxan-induced diabetic mice can significantly reduce blood glucose levels and water intake, and increase the body weight of diabetic mice. The results suggest SCP-BII attenuated the diabetes-induced weight loss, polydipsia and hyperglycemia, and these improvements suggest that Schisandra chinensis could be considered as a potential anti-diabetic agent.

Keywords: Schisandra chinensis; polysaccharide; purification; hypoglycemic; alloxan; anti-diabetic agent

Document Type: Research article

DOI: http://dx.doi.org/10.2174/157017809788681374

Publication date: 2009-07-01

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