The Effect of Phenyl Substituents on

Authors: Verbic, Tatjana Z.; Drakulic, Branko J.; Zloh, Mire; Juranic, Ivan O.

Source: Letters in Organic Chemistry, Volume 5, Number 8, December 2008 , pp. 692-699(8)

Publisher: Bentham Science Publishers

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Abstract:

Butanoic moiety of 4-aryl-2,4-dioxobutanoic acids is involved in interactions with metal ions within HIV-1 integrase active site. Sixteen congeneric 4-phenyl-2,4-dioxobutanoic acid derivatives with different substitution on the phenyl ring were prepared. Effects of substitution were studied by spectrometric methods (NMR, MS, UV/VIS) and linear free energy relationships. Better metal complexation ability of meta-alkyl substituted compounds, was observed. This observation might have pharmacological implications.

Keywords: 4-Aryl-2; 4-dioxobutanoic acids; Linear free energy relationships; NMR; MS; UV/VIS spectroscopy; metal complexation ability

Document Type: Research article

DOI: http://dx.doi.org/10.2174/157017808786857589

Publication date: 2008-12-01

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