Electrophilic Substitution Reaction of Indole: Part XXII-Synthesis of a Novel Spiro Heterocyclic System

Authors: Nayak, Anupam; Chatterjee, Asima; Banerji, Julie; Saha, Munmun; Manna, Sukumar; Kanrar, Sanchayita; Hirose, Tomoyasu

Source: Letters in Organic Chemistry, Volume 5, Number 5, July 2008 , pp. 403-406(4)

Publisher: Bentham Science Publishers

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Abstract:

The reaction of indole with acetone in the presence of mineral/Lewis acid continues to be a fascinating area for investigation since 1913, specially due to the instability of the indolyl carbinol being generated in situ. We report here the synthesis of a novel spiro heterocyclic system obtained during the study of this reaction using BF3.Et2O.

Keywords: Indole; acetone; spiro system; X-ray crystallography

Document Type: Research article

DOI: http://dx.doi.org/10.2174/157017808784872070

Publication date: 2008-07-01

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