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Synthesis of Melphalan-Gem-Bisphosphonate Conjugation to Bone Tumors and Study of Affinity to Hydroxyapatite In Vitro

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To develop a methodology for bone-specific delivery of drugs, a bone-targeting gem-bisphosphonate was used as a carrier of drugs. We had synthesized five compounds, which were a new class of potential bone-targeting reagents for bone tumors consisting of melphalan linked to a gem-bisphosphonate moiety through an amide linkage. The conjugates showed a high affinity to hydroxyapatite in vitro.

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Keywords: Bone-targeting; bone tumors; gem-bisphosphonates; melphalan

Document Type: Research Article

Publication date: 2008-04-01

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  • Letters in Organic Chemistry publishes original letters on all areas of organic chemistry including synthesis, bioorganic, medicinal, natural products, organometallic, supramolecular, molecular recognition and physical organic chemistry. The emphasis is placed on publishing quality papers very rapidly. Letters are processed rapidly and take full advantage of the Internet technology both for the submission and the review of the manuscripts.
    The journal is essential reading for all organic chemists both in academia and industry.
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