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Synthesis of NH-Aziridines from Vicinal Amino Alcohols Via the Wenker Reaction: Scope and Limitation

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The Wenker reaction is an efficient and practical method for the synthesis of NH-aziridines from vicinal amino alcohols. However, some limitation in the application has been reported. The scope and limitation of the Wenker reaction were investigated with a series of structurally diverse and representative vicinal amino alcohols.

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Keywords: Aziridine; Wenker reaction; amino alcohol; cyclization; heterocyclic compound; synthesis

Document Type: Research Article

Publication date: 2008-04-01

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  • Letters in Organic Chemistry publishes original letters on all areas of organic chemistry including synthesis, bioorganic, medicinal, natural products, organometallic, supramolecular, molecular recognition and physical organic chemistry. The emphasis is placed on publishing quality papers very rapidly. Letters are processed rapidly and take full advantage of the Internet technology both for the submission and the review of the manuscripts.
    The journal is essential reading for all organic chemists both in academia and industry.
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