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Efficient Acetylation and Boc Protection of Carbohydrates, Phenols and Amines

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An efficient acetylation and tert-butoxycarbonylation (Boc) of carbohydrate derivatives, phenols and amines catalyzed by tetrabutylammonium bromide is reported. The reaction condition is applicable to substrates containing acid and base labile functional groups. In most of the cases yields obtained were excellent.

Keywords: Carbohydrates; acetylation; amines; phenols; protecting groups; tert-butoxycarbonyl

Document Type: Research Article


Publication date: 2008-04-01

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  • Letters in Organic Chemistry publishes original letters on all areas of organic chemistry including synthesis, bioorganic, medicinal, natural products, organometallic, supramolecular, molecular recognition and physical organic chemistry. The emphasis is placed on publishing quality papers very rapidly. Letters are processed rapidly and take full advantage of the Internet technology both for the submission and the review of the manuscripts.
    The journal is essential reading for all organic chemists both in academia and industry.
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