Regioselective Synthesis of Oxepin and Oxocin Annulated Quinoline Heterocycles by Ring-Closing Metathesis

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Abstract:

Regioselective synthesis of oxepin and oxocin annulated quinoline heterocycles by the combination of Claisen rearrangement and ring-closing metathesis reaction is described. The ring-closing metathesis (RCM) and ring-closing enyne metathesis (RCEM) proceeded smoothly in the presence of Grubbs' catalyst A or B in toluene under nitrogen atmosphere without deactivation of the basic quinoline nitrogen.





Keywords: Grubb's catalyst; Ring-closing metathesis; oxepine; oxocine; quinoline derivatives

Document Type: Research Article

DOI: http://dx.doi.org/10.2174/157017808783955871

Publication date: April 1, 2008

More about this publication?
  • Letters in Organic Chemistry publishes original letters on all areas of organic chemistry including synthesis, bioorganic, medicinal, natural products, organometallic, supramolecular, molecular recognition and physical organic chemistry. The emphasis is placed on publishing quality papers very rapidly. Letters are processed rapidly and take full advantage of the Internet technology both for the submission and the review of the manuscripts.
    The journal is essential reading for all organic chemists both in academia and industry.
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