Regioselective Synthesis of Oxepin and Oxocin Annulated Quinoline Heterocycles by Ring-Closing Metathesis
Regioselective synthesis of oxepin and oxocin annulated quinoline heterocycles by the combination of Claisen rearrangement and ring-closing metathesis reaction is described. The ring-closing metathesis (RCM) and ring-closing enyne metathesis (RCEM) proceeded smoothly in the presence of Grubbs' catalyst A or B in toluene under nitrogen atmosphere without deactivation of the basic quinoline nitrogen.
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Document Type: Research Article
Publication date: 2008-04-01
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