Synthesis and Antitumor Activities of 3-Substituted 1-(5-formylfurfuryl)indolin-2-one Derivatives

Authors: Zhou, Fusheng; Zheng, Jianbin; Dong, Xiaochun; Zhang, Zhiwen; Zhao, Lingling; Sha, Xianyi; Li, Lin; Wen, Ren

Source: Letters in Organic Chemistry, Volume 4, Number 8, December 2007 , pp. 601-605(5)

Publisher: Bentham Science Publishers

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Abstract:

Forty-two 3-substituted 1-(5-formylfurfuryl)indolin-2-ones were synthesized and most of these compounds exhibited potent inhibitory activities against P. oryzae (MIC = 0.78-25 μg/mL) and human intestinal Caco-2 cells (IC50 = 0.19-9.42 μM). Eight compounds selected for further screening also showed inhibitory activities (IC50 = 1.84-10.32 μM) against human lung adenocarcinoma cells (SPC-A1).

Keywords: 3-Substituted 1-(5-formylfurfuryl)indolin-2-ones; antitumor activity; antifungal activity; Pyricoraria oryzae; Caco-2 cells; SPC-A1

Document Type: Research article

DOI: http://dx.doi.org/10.2174/157017807782795484

Publication date: 2007-12-01

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