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One-Pot Synthesis of 1,3-Thiazolidin-4-Ones Derivatives from 2-Amino-1,3,4-Thiadiazole

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Several 1,3-thiazolidin-4-ones were synthesized by cyclocondensation reaction of 2-amino-1,3,4-thiadiazole, mercaptoacetic acid and various arenealdehydes in moderate to good yields. These compounds were characterized by 1H, 13C and 19F NMR. The antimalarial activity of thiazolidinones was evaluated in vitro against Plasmodium falciparum clone but none of them showed activity at maximum concentration (50μg/ml) used.

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Keywords: 4-thiazolidinone; cyclocondensation; heterocycles

Document Type: Research Article

Publication date: 2007-10-01

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    The journal is essential reading for all organic chemists both in academia and industry.
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