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The Efficient One-Step Synthesis of Protected 6-Alkyl(aryl)-2-acetylamino-4(3H)-pyrimidinones

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Abstract:

The one-step synthesis of a new series of protected 6-alkyl- and 6-aryl-2-acetylamino-4(3H)-pyrimidinones, where alkyl = CH3; aryl = Ph, 4-CH3Ph, 4-FPh, 4-ClPh, 4-BrPh and 4-OCH3Ph from the reaction of 4-methoxy-1,1,1- trichloroalk-3-en-2-ones with 1-acetylguanidine in acetonitrile as solvent is reported. The acetylamino group of 2- acetylamino-4(3H)-pyrimidinones has also been hydrolyzed under three different conditions to afford the corresponding free 2-aminopyrimidinones.





Keywords: Aminopyrimidines; deprotection; haloform reaction; heterocycles; ketones; pyrimidinones

Document Type: Research Article

Publication date: 2007-10-01

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    The journal is essential reading for all organic chemists both in academia and industry.
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