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Reductive Amination of Carbonyl Compounds with NaBH4-H3PW12O40 in THF and Under Solvent-Free Conditions

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A simple, completely chemoselective, and convenient procedure for reductive amination of aldehydes and ketones using NaBH4 in the presence of H3PW12O40 in THF and under solvent-free conditions at ambient temperature is described.

Keywords: H3PW12O40; NaBH4; Reductive amination; solvent-free conditions

Document Type: Research Article

Publication date: October 1, 2007

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  • Letters in Organic Chemistry publishes original letters on all areas of organic chemistry including synthesis, bioorganic, medicinal, natural products, organometallic, supramolecular, molecular recognition and physical organic chemistry. The emphasis is placed on publishing quality papers very rapidly. Letters are processed rapidly and take full advantage of the Internet technology both for the submission and the review of the manuscripts.
    The journal is essential reading for all organic chemists both in academia and industry.

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