Asymmetric Aldol Additions with a Titanium Enolate of N-Thioglycolyl Oxazolidinethione
Authors: Ortiz, Aurelio; Sabala, Rocio; Sansinenea, Estibaliz; Bernes, Sylvain
Source: Letters in Organic Chemistry, Volume 4, Number 7, October 2007 , pp. 456-461(6)
Publisher: Bentham Science Publishers
Abstract:A titanium enolate of N-thioglycolyl oxazolidinethione has been prepared and used for the synthesis of "Evans" syn aldol adducts, in good yield and high selectivity. Removal of the chiral auxiliary was accomplished by reduction to the corresponding 1,3-diols or by preparation of Weinreb amides.
Document Type: Research Article
Publication date: October 2007
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