Regioselective Synthesis of Biologically Important Scaffold Spiro [Indole- Perimidines]: An Antitumor Agents

Authors: Kapil Arya,; Anshu Dandia,

Source: Letters in Organic Chemistry, Volume 4, Number 5, July 2007 , pp. 378-383(6)

Publisher: Bentham Science Publishers

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Abstract:

Regioselective synthesis of spiro [indole -3(3H), 2' (3H)perimidine]2'(1H)one (4a-e) for potential application in cancer treatment under conventionally and microwave irradiation using different solvents/solid support has been studied. A judicious choice of the reaction conditions allowed the titled product 4a-e to be generated in excellent yields.

Keywords: Perimidine; indole 2,3-dione; microwave; 1,8-diaminonapthalene; montmorillonite KSF; cytotoxic

Document Type: Research article

DOI: http://dx.doi.org/10.2174/157017807781212175

Publication date: 2007-07-01

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