Synthesis and Cytotoxic Activity of Steroidal Phosphorothioate,Phosphoroselenoate, and Phosphate Derivatives Conjugated with 3'-Azido-3'-Deoxythymidine
Some steroidal phosphorothioate, phosphoroselenoate, and phosphate derivatives conjugated with 3'-Azido-3'-deoxythymidine (AZT) have been synthesized in good yields and their structures were confirmed on the basis of spectral methods. The result has shown that some of bioconjugates possess activity against breast cancer MCF-7 in bioassay.
Keywords: AZT; Steroidal conjugate; cytotoxic activity; phosphate
Document Type: Research Article
Publication date: 01 April 2007
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