A Highly Efficient Low Temperature Modification of the Classical Ullmann Reaction

Authors: Leroux, Frederic R.; Simon, Roger; Nicod, Nathalie

Source: Letters in Organic Chemistry, Volume 3, Number 12, December 2006 , pp. 948-954(7)

Publisher: Bentham Science Publishers

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Abstract:

The efficient synthesis of sterically demanding tetra-substituted biaryls by means of a one-pot threestep low-temperature modification of the classical Ullmann reaction is reported. The major benefit of this methodology lies in the ready synthesis of polybrominated biaryls, which can be subsequently functionalized into various target molecules by means of regioselective halogen/metal permutations.

Keywords: Ullmann reaction; C-C coupling; aryllithium; copper

Document Type: Research article

DOI: http://dx.doi.org/10.2174/157017806779467979

Affiliations: 1: Laboratoire de Stereochimie (UMR CNRS 7509), Universite Louis Pasteur (ECPM), 25 rue Becquerel, F - 67087 Strasbourg, France.

Publication date: 2006-12-01

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