Versatile Synthesis of MRI Contrast Agents Based on Carbon-Substituted Triazacycloalkanes

Authors: Jaakkola, Lassi; Hovinen, Jari

Source: Letters in Organic Chemistry, Volume 3, Number 8, August 2006 , pp. 643-647(5)

Publisher: Bentham Science Publishers

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Abstract:

3-(4-Iodophenoxy)-tris(2-nitrobenzenesulfonyl)-1,4,7-triazacyclodecane (5a) was synthesized by a Mitsunobu reaction between pernosylated diethylenetriamine (4a) and 1,3-bis(trityloxy)propan-2-ol (2). 5a served as a key intermediate in the preparation of MRI contrast agents allowing biomolecule labeling both in solution and on solid phase.

Keywords: MRI; labeling; azamacrocycle; Mitsunobu reaction

Document Type: Research article

DOI: http://dx.doi.org/10.2174/157017806778559491

Affiliations: 1: PerkinElmer Life and Analytical Sciences, Turku Site, P.O. Box 10, FIN-20101 Turku, Finland.

Publication date: 2006-08-01

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