Methyl 2-Methoxycarbonyl-3-Phenylpropionate Derivatives: A New Type of Angiotensin Converting Enzyme Inhibitors

Authors: Cai, Xiao-Hua; Xie, Bing; Guo, Hui

Source: Letters in Organic Chemistry, Volume 3, Number 6, June 2006 , pp. 492-494(3)

Publisher: Bentham Science Publishers

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Abstract:

Methyl 2-methoxycarbonyl-3-phenylpropionate derivatives were prepared, and their inhibitory activities for angiotensin converting enzyme (ACE) were evaluated. The inhibitiory activity of methyl 3-{4-[2- [N-(4-methylbenzylphenyl)methyl,N-methylamino]ethoxy]phenyl} -2-methoxycarbonylpropionate (5b, IC50 = 0.0039 μM) and methyl 3-{4-[2-[N-bis(4-methoxy phenyl)methyl,N-methylamino]ethoxy]phenyl}-2- methoxycarbonylpropionate (5d, IC50 = 0.0027 μM) was higher than that of control drug captopril (IC50 = 0.0075 μM).

Keywords: Hypertension; 2-methoxycarbonyl-3-phenyl propionate derivative; ACE inhibitor

Document Type: Research article

DOI: http://dx.doi.org/10.2174/157017806777828484

Affiliations: 1: College of Chemistry and environmental Science, Guizhou University for Nationalites, Guiyang 550025, P. R. China.

Publication date: 2006-06-01

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