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Synthesis of Polyhydroquinoline Derivatives Under Solvent-Free Conditions

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A series of 1,4- dihydropyridines derivatives have been obtained by the reaction of chalcones with dimedone in the presence of ammonium formate under solvent-free conditions. Each title compound was formed in good yield. The structure of these compounds has been thoroughly studied by X-ray crystallographic analysis.

Keywords: 1,4-dihydropyridines; chalcone; crystal structure; dimedone; solvent-free

Document Type: Research Article


Affiliations: College of Chemistry and Chemical Engineering, Suzhou (Soochow) University, Suzhou, 215123 China.

Publication date: April 1, 2006

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  • Letters in Organic Chemistry publishes original letters on all areas of organic chemistry including synthesis, bioorganic, medicinal, natural products, organometallic, supramolecular, molecular recognition and physical organic chemistry. The emphasis is placed on publishing quality papers very rapidly. Letters are processed rapidly and take full advantage of the Internet technology both for the submission and the review of the manuscripts.
    The journal is essential reading for all organic chemists both in academia and industry.

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