A Radical Route to a cis-3,5-Dialkyl Proline Derivative
Abstract:β-Amino alcohols possessing an alkynyl functionality were converted into bicyclic compounds via a 5-exo-dig radical cyclization. One of this bicyclic product was transformed in three steps into the (2R,3S,5S)- 3-methyl-5-iso-propyl proline.
Document Type: Research Article
Affiliations: Universite Pierre et Marie Curie-Paris 6, Laboratoire de Chimie Organique-equipe Synthese Asymetrique (UMR CNRS 7611), Institut de Chimie Moleculaire (FR 2769), Case 47, 4 Place Jussieu, F-75252 Paris Cedex 05, France.
Publication date: April 1, 2006
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