A One-Pot Synthesis of D-Ribonucleosides Using Natural Phosphate Doped with KI in HMDS

Authors: Lazrek, Hassan B.; Ouzebla, Driss; Rochdi, Abdellali; Redwane, Nezha; Vasseur, Jean-Jacques

Source: Letters in Organic Chemistry, Volume 3, Number 4, April 2006 , pp. 313-314(2)

Publisher: Bentham Science Publishers

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Abstract:

Potassium iodide supported on natural phosphate in HMDS was used as a promotor in the condensation of 1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose with trimethylsilylated nucleobases, under mild conditions, to provide several D-ribonucleosides.





Keywords: Natural phosphate; nucleosides; potassium iodide

Document Type: Research Article

DOI: http://dx.doi.org/10.2174/157017806776114531

Affiliations: Faculty of Sciences Semlalia, 40000 Marrakesh Morocco.

Publication date: April 1, 2006

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  • Letters in Organic Chemistry publishes original letters on all areas of organic chemistry including synthesis, bioorganic, medicinal, natural products, organometallic, supramolecular, molecular recognition and physical organic chemistry. The emphasis is placed on publishing quality papers very rapidly. Letters are processed rapidly and take full advantage of the Internet technology both for the submission and the review of the manuscripts.
    The journal is essential reading for all organic chemists both in academia and industry.
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