@article {Kouznetsov:2006:1570-1786:300,
title = "A Straightforward Synthetic Approach to Antitumoral Pyridinyl Substituted 7H-Indeno[2,1-c]Quinoline Derivatives Via Three-Component Imino Diels- Alder Reaction",
journal = "Letters in Organic Chemistry",
parent_itemid = "infobike://ben/loc",
publishercode ="ben",
year = "2006",
volume = "3",
number = "4",
publication date ="2006-04-01T00:00:00",
pages = "300-304",
itemtype = "ARTICLE",
issn = "1570-1786",
url = "https://www.ingentaconnect.com/content/ben/loc/2006/00000003/00000004/art00012",
doi = "doi:10.2174/157017806776114595",
keyword = "imino Diels-Alder reaction, Multi-component reaction, antitumoral and antifungal activities, indeno[2,1-c]quinolines",
author = "Kouznetsov, Vladimir V. and Puentes, Cristian O. and Bohorquez, Arnold R.R. and Zacchino, Susana A. and Sortino, Maximiliano and Gupta, Mahabir and Vazquez, Yelkaira and Bahsas, Ali and Amaro-Luis, Juan",
abstract = "A simple and efficient synthetic method of obtaining pyridinyl substituted indeno[2,1-c]quinoline derivatives has been developed. This method involves a three-component imino Diels-Alder cycloaddition between anilines, pyridinecarboxyaldehydes and indene as the key ring forming step and subsequent treatment of obtained 5,6,6a,11b-tetrahydroindeno[2,1-c]quinolines with powdered sulfur to give corresponding indeno[2,1-c]quinolines. Some of them were treated with potassium permanganate in acetone to afford the 7Hindeno[ 2,1-c]quinolin-7-ones. Most compounds of the series were devoid of antifungal properties against a panel of standard dermatophytes, however, nearly all of them were active against breast (MCF-7), lung (H-460) and central nervous system (SF-268) human cancer cell lines. ",
}