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"On Water": Rapid Knoevenagel Condensation Using Sodium Pyruvate

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A high yielding and fast method of Knoevenagel condensation of malononitrile and ethylcyanoacetate with various aldehydes using sodium pyruvate in aqueous media is described.

Keywords: Knoevenagel; aqueous media; rapid reaction; sodium pyruvate

Document Type: Research Article


Affiliations: Department of Chemistry, School of Sciences Azzahra University, Vanak.Tehran, Iran.

Publication date: April 1, 2006

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  • Letters in Organic Chemistry publishes original letters on all areas of organic chemistry including synthesis, bioorganic, medicinal, natural products, organometallic, supramolecular, molecular recognition and physical organic chemistry. The emphasis is placed on publishing quality papers very rapidly. Letters are processed rapidly and take full advantage of the Internet technology both for the submission and the review of the manuscripts.
    The journal is essential reading for all organic chemists both in academia and industry.

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