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Synthesis of 5-Substituted-1,3,4-Oxadiazole-2(3H)-Thiones Under Microwave Irradiation

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A variety of 5-substituted-1,3,4-oxadiazole-2(3H)-thiones were prepared using microwave irradiation as energy source under solvent-free conditions. Reaction times were reduced from 5-14 h to 3-7 min affording high yields from corresponding acyl and aroyl hydrazides.

Keywords: 4-oxadiazolethiones; 5-substituted-1,3; microwave-assisted synthesis

Document Type: Research Article


Affiliations: H.E.J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi-75270, Pakistan.

Publication date: April 1, 2006

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  • Letters in Organic Chemistry publishes original letters on all areas of organic chemistry including synthesis, bioorganic, medicinal, natural products, organometallic, supramolecular, molecular recognition and physical organic chemistry. The emphasis is placed on publishing quality papers very rapidly. Letters are processed rapidly and take full advantage of the Internet technology both for the submission and the review of the manuscripts.
    The journal is essential reading for all organic chemists both in academia and industry.

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