A Silica-Supported Copper(I) Catalyzed Sonogashira Coupling Reaction
Authors: Zhang, Liyuan; Li, Pinhua; Wang, Lei
Source: Letters in Organic Chemistry, Volume 3, Number 4, April 2006 , pp. 282-285(4)
Publisher: Bentham Science Publishers
Abstract:An immobilization of copper(I) in organic-inorganic hybrid materials catalyzed Sonogashira coupling reaction was developed. Terminal alkynes reacted with aryl iodides and aryl bromides in the presence of 3-(2-aminoethylamino)propyl functionalized silica gel immobilized copper(I) catalyst, triphenylphosphine and potassium carbonate in DMF. The reactions generated the corresponding cross-coupling products in good to excellent yields. Furthermore, silica-supported copper was recovered and recycled by a simple filtration of the reaction solution and used for six consecutive trials without decreases in activity.
Document Type: Research article
Publication date: 2006-04-01
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