A Silica-Supported Copper(I) Catalyzed Sonogashira Coupling Reaction

Authors: Zhang, Liyuan; Li, Pinhua; Wang, Lei

Source: Letters in Organic Chemistry, Volume 3, Number 4, April 2006 , pp. 282-285(4)

Publisher: Bentham Science Publishers

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Abstract:

An immobilization of copper(I) in organic-inorganic hybrid materials catalyzed Sonogashira coupling reaction was developed. Terminal alkynes reacted with aryl iodides and aryl bromides in the presence of 3-(2-aminoethylamino)propyl functionalized silica gel immobilized copper(I) catalyst, triphenylphosphine and potassium carbonate in DMF. The reactions generated the corresponding cross-coupling products in good to excellent yields. Furthermore, silica-supported copper was recovered and recycled by a simple filtration of the reaction solution and used for six consecutive trials without decreases in activity.

Keywords: Sonogashira coupling reaction; organic-inorganic hybrid material; immobilization of copper(I); heterogeneous catalyst

Document Type: Research article

DOI: http://dx.doi.org/10.2174/157017806776114559

Affiliations: 1: Department of Chemistry, Huaibei Coal Teachers College, Huaibei, Anhui 235000, P. R. China.

Publication date: 2006-04-01

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