Cyanosilylation of Hetero-Substituted Ketones Catalyzed by LiCl
Authors: Kurono, Nobuhito; Suzuki, Ken; Ohkuma, Takeshi
Source: Letters in Organic Chemistry, Volume 3, Number 4, April 2006 , pp. 275-277(3)
Publisher: Bentham Science Publishers
Abstract:LiCl efficiently catalyzes cyanosilylation of various hetero-substituted ketones. α,α-Dialkoxy ketones are completely converted to silylated cyanohydrins with a substrate-to-catalyst molar ratio of 100,000 at room temperature. Acetophenones substituted by an electron-attracting group at the ortho or para position show higher reactivity than substrates with an electron-donating function.
Document Type: Research Article
Affiliations: Division of Chemical Process Engineering, Graduate School of Engineering, Hokkaido University, Sapporo 060-8628, Japan.
Publication date: April 1, 2006
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