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Silphos [PCl3-n(SiO2)n], a Heterogeneous Phosphine Reagent Mediated the Conversion of Oximes to Nitriles and Amides or Carbonyl Compounds

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Abstract:

Silphos [PCl3-n(SiO2)n], a heterogeneous phosphine reagent provides a facile and efficient method for the dehydration of aldoximes and Beckmann rearrangement of ketoximes in CH3CN at room temperature without occurrence of any deprotection reaction. Silphos also deprotects oximes in the presence of catalytic amounts of molecular bromine in excellent yields. The separation of the produced Silphos oxide is chromatography-free and simply by filtration.





Keywords: Beckmann rearrangement; Silphos; aldoxime; amide; dehydration; deprotection; ketoxime; nitrile

Document Type: Research Article

DOI: https://doi.org/10.2174/157017806776114504

Affiliations: Department of Chemistry, College of Sciences, Shiraz University, Shiraz 71454, Iran.

Publication date: 2006-04-01

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    The journal is essential reading for all organic chemists both in academia and industry.
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