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Clean and Facile Condensations Reaction of Indoles and Carbonyl Compounds Under Solvent-Free Conditions

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A simple, rapid, atom economy and highly efficient green protocol has been developed for the reactions of indole with carbonyl compounds under solvent- free conditions. The attractive features of these procedures are the mild reaction conditions, high conversions, cleaner reaction profiles, inexpensive and environmentally friendly lithium perchlorate and short reaction times.

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Keywords: atom economy; bis indole; carbonyl compounds; indole; lithium perchlorate

Document Type: Research Article

Affiliations: Department of Chemistry, Sharif University of Technology, P. O. Box 11465-9516 Terhran, Iran.

Publication date: 2006-02-01

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  • Letters in Organic Chemistry publishes original letters on all areas of organic chemistry including synthesis, bioorganic, medicinal, natural products, organometallic, supramolecular, molecular recognition and physical organic chemistry. The emphasis is placed on publishing quality papers very rapidly. Letters are processed rapidly and take full advantage of the Internet technology both for the submission and the review of the manuscripts.
    The journal is essential reading for all organic chemists both in academia and industry.
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