KF/Al2O3 Mediated Aza-Michael Addition of Indoles to Electron-Deficient Olefins
Abstract:KF/Al2O3 efficiently catalyzes aza-Michael addition of indole and 3-methylindole to a variety of electron-deficient conjugated alkenes such as α,β-unsaturated ketones, amides and nitriles. The N-alkylation adducts are produced in good to excellent yields and relatively in short times. The catalyst can be recycled for subsequent reactions without any appreciable loss of efficiency.
Document Type: Research Article
Affiliations: Sharif University of Technology, Department of Chemistry, PO Box 11365- 9516, Tehran, Iran.
Publication date: February 1, 2006
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