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KF/Al2O3 Mediated Aza-Michael Addition of Indoles to Electron-Deficient Olefins

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KF/Al2O3 efficiently catalyzes aza-Michael addition of indole and 3-methylindole to a variety of electron-deficient conjugated alkenes such as α,β-unsaturated ketones, amides and nitriles. The N-alkylation adducts are produced in good to excellent yields and relatively in short times. The catalyst can be recycled for subsequent reactions without any appreciable loss of efficiency.

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Keywords: Electron-deficient olefins; Indole; KF/Al2O3; N-alkylation; aza-Michael addition

Document Type: Research Article

Affiliations: Sharif University of Technology, Department of Chemistry, PO Box 11365- 9516, Tehran, Iran.

Publication date: 2006-02-01

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