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An Efficient and Eco-Friendly Procedure for the Synthesis of Hantzsch Ethyl 1,4-Dihydro-2,6-Dimethylpyridine-3,5-Dicarboxylates Under Mild and Green Conditions

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A mixture of ethyl acetoacetate and various aldehydes in the presence of ammonium salts was converted to Hantzsch ethyl 1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylates under mild and green conditions with good to excellent yields.

Keywords: 1,4-dihydroyridines; 3,5-dicarboxylate; 6-dimethylpyridine-3; Hantzsch synthesis; ammonium salts; ethyl 1,4-dihydro-2; green conditions; solvent-free conditions

Document Type: Research Article

Affiliations: Chemistry Department, College of Science, Bu-Ali Sina University, Hamadan, 65174, Iran.

Publication date: February 1, 2006

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  • Letters in Organic Chemistry publishes original letters on all areas of organic chemistry including synthesis, bioorganic, medicinal, natural products, organometallic, supramolecular, molecular recognition and physical organic chemistry. The emphasis is placed on publishing quality papers very rapidly. Letters are processed rapidly and take full advantage of the Internet technology both for the submission and the review of the manuscripts.
    The journal is essential reading for all organic chemists both in academia and industry.

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