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An Efficient and Eco-Friendly Procedure for the Synthesis of Hantzsch Ethyl 1,4-Dihydro-2,6-Dimethylpyridine-3,5-Dicarboxylates Under Mild and Green Conditions

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A mixture of ethyl acetoacetate and various aldehydes in the presence of ammonium salts was converted to Hantzsch ethyl 1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylates under mild and green conditions with good to excellent yields.

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Keywords: 1,4-dihydroyridines; 3,5-dicarboxylate; 6-dimethylpyridine-3; Hantzsch synthesis; ammonium salts; ethyl 1,4-dihydro-2; green conditions; solvent-free conditions

Document Type: Research Article

Affiliations: Chemistry Department, College of Science, Bu-Ali Sina University, Hamadan, 65174, Iran.

Publication date: 01 February 2006

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