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Synthesis and Biological Evaluation of a New Benzofuran Analogue of 8- HETE

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The total synthesis of a 2,3-disubstituted benzofuran, designed as a structural analogue of a bioactive arachidonic acid metabolite, the 8-(S)-HETE, is reported. This heterocyclic derivative has been evaluated as dual agonist of the PPARα and PPARγ nuclear receptors.

Keywords: 8-HETE; PPARs; benzofuran

Document Type: Research Article

Affiliations: ENSCR, Laboratoire de Syntheses et Activations de Biomolecules, UMR-CNRS 6052, Avenue du General Leclerc, 35700 Rennes-Beaulieu, France.

Publication date: February 1, 2006

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  • Letters in Organic Chemistry publishes original letters on all areas of organic chemistry including synthesis, bioorganic, medicinal, natural products, organometallic, supramolecular, molecular recognition and physical organic chemistry. The emphasis is placed on publishing quality papers very rapidly. Letters are processed rapidly and take full advantage of the Internet technology both for the submission and the review of the manuscripts.
    The journal is essential reading for all organic chemists both in academia and industry.

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