Synthesis and Biological Evaluation of a New Benzofuran Analogue of 8- HETE
Abstract:The total synthesis of a 2,3-disubstituted benzofuran, designed as a structural analogue of a bioactive arachidonic acid metabolite, the 8-(S)-HETE, is reported. This heterocyclic derivative has been evaluated as dual agonist of the PPARα and PPARγ nuclear receptors.
Document Type: Research Article
Affiliations: ENSCR, Laboratoire de Syntheses et Activations de Biomolecules, UMR-CNRS 6052, Avenue du General Leclerc, 35700 Rennes-Beaulieu, France.
Publication date: February 1, 2006
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